Cajun Slow Cooked Brisket Recipe

Cajun Slow Cooked Brisket is super flavorful and tender and the perfect dish to serve for a brunch or backyard barbecue.

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Cajun Spiced Slow Cooked Brisket

Prep Time: 10 minutes
Cook Time: 7 hours 20 minutes
Resting time: 10 minutes
Total Time: 7 hours 30 minutes
Servings: 8 servings
Calories: 216kcal
Author: Kelly DiMascio
Searing and lightly smoking the brisket on the grill first and finishing it in the slow cooker makes this the perfect easy dish for a special brunch or dinner.
Cajun Spice Mix
Honey Barbecue Sauce
Print Recipe


Brisket Rub:

  • Cajun Spice Mix - cajun spice mix recipe link in notes or use your favorite
  • 1/4 cup brown sugar

For the Brisket

  • 1 1/2 lbs beef brisket
  • 3/4 Cup Homemade Honey Barbecue Sauce - recipe link in notes or use your favorite bottled sauce
  • 3 T Worcestershire sauce
  • 2 T Tabasco
  • 1/2 sweet onion - sliced into rings
  • Mesquite Wood chips - soaked in water


  • Mix Cajun spice mix and brown sugar together in a bowl; rub evenly over the surface of the brisket.
  • Put the brisket in a large, resealable plastic bag; refrigerate 30 minutes to overnight.
  • Place smoker box with water soaked mesquite wood chips. Preheat grill to high - about 500 degrees. Sear Cajun Spice rubbed brisket over very high heat until outside is well charred, about 10 minutes.
  • Stir barbecue sauce, Tabasco and Worcestershire sauce together in the bottom of a slow cooker.
  • Lay brisket into the sauce mixture.
  • Arrange onions atop the brisket.
  • Cook on Low until brisket is very tender, 6 to 7 hours.
  • Rest brisket 10 minutes before slicing or shredding; serve with sauce from the slow cooker.


Alternative Searing and Smoke Method:
If you don't have access to a grill, you can sear the brisket in a skillet on the stovetop. To add the smokey flavor - add a tablespoon of liquid smoke and 2 tablespoons of smoked paprika.
Cajun Spice Mix
Homemade Honey Barbecue Sauce


Calories: 216kcal | Carbohydrates: 20g | Protein: 18g | Fat: 6g | Saturated Fat: 2g | Cholesterol: 52mg | Sodium: 494mg | Potassium: 432mg | Sugar: 17g | Vitamin A: 60IU | Vitamin C: 4.5mg | Calcium: 30mg | Iron: 2.3mg
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