Cajun Slow Cooked Brisket Recipe

Cajun Slow Cooked Brisket is super flavorful and tender and the perfect dish to serve for a brunch or backyard barbecue.

Cajun Spiced Slow Cooked Brisket

Course: Main, Main Course
Cuisine: American, cajun, creole, New Orleans, Southern
Prep Time: 10 minutes
Cook Time: 7 hours 20 minutes
Resting time: 10 minutes
Total Time: 7 hours 30 minutes
Servings: 8 servings
Calories: 216 kcal
Author: Kelly DiMascio
Searing and lightly smoking the brisket on the grill first and finishing it in the slow cooker makes this the perfect easy dish for a special brunch or dinner.

Cajun Spice Mix

Honey Barbecue Sauce



Brisket Rub:

  • Cajun Spice Mix cajun spice mix recipe link in notes or use your favorite
  • 1/4 cup brown sugar

For the Brisket

  • 1 1/2 lbs beef brisket
  • 3/4 Cup Homemade Honey Barbecue Sauce recipe link in notes or use your favorite bottled sauce
  • 3 T Worcestershire sauce
  • 2 T Tabasco
  • 1/2 sweet onion sliced into rings
  • Mesquite Wood chips soaked in water


  1. Mix Cajun spice mix and brown sugar together in a bowl; rub evenly over the surface of the brisket.
  2. Put the brisket in a large, resealable plastic bag; refrigerate 30 minutes to overnight.
  3. Place smoker box with water soaked mesquite wood chips. Preheat grill to high - about 500 degrees. Sear Cajun Spice rubbed brisket over very high heat until outside is well charred, about 10 minutes.
  4. Stir barbecue sauce, Tabasco and Worcestershire sauce together in the bottom of a slow cooker.
  5. Lay brisket into the sauce mixture.
  6. Arrange onions atop the brisket.
  7. Cook on Low until brisket is very tender, 6 to 7 hours.
  8. Rest brisket 10 minutes before slicing or shredding; serve with sauce from the slow cooker.

Recipe Notes



Alternative Searing and Smoke Method:


If you don't have access to a grill, you can sear the brisket in a skillet on the stovetop. To add the smokey flavor - add a tablespoon of liquid smoke and 2 tablespoons of smoked paprika.



Cajun Spice Mix


Homemade Honey Barbecue Sauce


Nutrition Facts
Cajun Spiced Slow Cooked Brisket
Amount Per Serving
Calories 216 Calories from Fat 54
% Daily Value*
Fat 6g9%
Saturated Fat 2g13%
Cholesterol 52mg17%
Sodium 494mg21%
Potassium 432mg12%
Carbohydrates 20g7%
Sugar 17g19%
Protein 18g36%
Vitamin A 60IU1%
Vitamin C 4.5mg5%
Calcium 30mg3%
Iron 2.3mg13%
* Percent Daily Values are based on a 2000 calorie diet.



  1. Mother's Day Brunch Menu | Happy Mother's Day | Mermaids & Mojitos - […] Cajun Slow Cooker BBQ Brisket […]

Submit a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.

More Recipe(

 < Eat  < Drink < Party <

How to make Irish Coffee

Learn how to make Irish Coffee
An Irish coffee cocktail is a mixture of brown sugar-sweetened coffee, Irish whiskey, and topped with whipped cream.
This is so easy to make and prepare to feel pampered and enveloped by this warm coffee cocktail. 


DIY + Create

Food Philosophy

I love serving homemade meals and entertaining, but I don’t love spending all my time in the kitchen… Sound familiar?  I’ll share my shortcuts for getting delicious, healthy food on the table – easy, fast & stress-free. All of my recipes have been tested on family and friends.  We love them and I hope you will too.



Chief Mermaid & Mojito Maker

This is me hangin’ out on the boat – it’s an absolutely gorgeous day in the Florida Keys – doing what wannabe mermaids do best…splashing in the waves + soaking up the sun. Life’s amazing.  Want to learn more?  

Pin It on Pinterest

Share This

Share the Love.

Tell your friends!

Share via
Copy link
Powered by Social Snap